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FINBAR - Factors INfluencing the Barrett's/Adenocarcinoma Relationship
Status:
Cancer(s):
Research theme(s):
Research workstream(s):
Related staff:
Collaborators & co-investigators:
Dr Lesley Anderson, Queen’s University Belfast
Dr Marie Cantwell, Queen’s University Belfast
Prof Liam Murray, Queen’s University Belfast
Funding source:
Northern Ireland Research & Development Office
The FINBAR study is an all-Ireland case-control study investigating risk factors for oesophageal adenocarcinoma and precursor lesions, Barrett’s oesophagus and reflux oesophagitis. The study is led by colleagues at Queen’s University Belfast. Detailed information on diet, lifestyle and medical history, together with DNA and biological samples, has been collected from 230 patients with adenocarcinoma, 223 with Barrett's oesophagus, 225 with reflux oesphagitis and 249 control subjects. Several papers have been published from the project.
The National Cancer Registry is leading work on the role of folate and related dietary factors, and genetic variation in folate metabolism, in the aetiology of these lesions.
- Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortium
- Nonsteroidal anti-inflammatory drugs and the esophageal inflammation-metaplasia-adenocarcinoma sequence
- Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma
- Intakes of dietary folate and other B vitamins are associated with risks of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis
- Genes of the Interleukin-18 Pathway Are Associated With Susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma
- The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium
- Vitamin D, calcium and dairy intake, and risk of oesophageal adenocarcinoma and its precursor conditions
- Risk of Barrett's oesophagus, oesophageal adenocarcinoma and reflux oesophagitis and the use of nitrates and asthma medications
- Relationship between Helicobacter pylori infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence: results from the FINBAR case-control study
- A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma
- Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study
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